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Julian Rode, Maja Novak, Benjamin M. Friedrich: Information theory of chemotactic agents using both spatial and temporal gradient sensing, EPL 05/2022; 138 12001, DOI:10.1209/0295-5075/ac6620
Biological cells and small organisms navigate in concentration fields of signaling molecules using two fundamental gradient-sensing strategies: spatial comparison of concentrations measured at different positions on their surface and temporal comparison of concentrations measured at different locations visited along their motion path. It is believed that size and speed dictate which gradient-sensing strategy cells choose, yet this has never been formally proven. Using information theory, we investigate the optimal gradient-sensing mechanism for an ideal chemotactic agent that combines spatial and temporal comparisons. We account for the physical limits of chemosensation: molecule counting noise at physiological concentrations and motility noise inevitable at the microscale. Our simulation data collapse onto an empirical power law that predicts an optimal weighting of information as a function of motility and sensing noise, demonstrating how spatial comparison becomes more beneficial for agents that are large, slow, and less persistent. This refines and quantifies the previous heuristic notion. Our idealized model assuming unlimited information processing capabilities serves as a benchmark for the chemotaxis of biological cells.
All publications
Andrea Auconi, Maja Novak, Benjamin M. Friedrich
Gradient sensing in Bayesian chemotaxis.
EPL 05/2022; 138 12001
DOI:10.1209/0295-5075/ac6620
Link
Maja Novak, Benjamin M. Friedrich
Bayesian gradient sensing in the presence of rotational diffusion.
New J. Phys. 04/2021; 23:043026.
DOI:10.1088/1367-2630/abdb70
Link
Maja Novak, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W. Thomae, Iva M. Tolić, Nenad Pavin
The mitotic spindle is chiral due to torques within microtubule bundles.
Nat. Commun. 12/2018; 9(1).
DOI:10.1038/s41467-018-06005-7
Link
Janko Kajtez, Anastasia Solomatina, Maja Novak, Bruno Polak, Kruno Vukušić, Jonas Rüdiger, Gheorghe Cojoc, Ana Milas, Ivana Š. Šestak, Patrik Risteski, Federica Tavano, Anna H Klemm, Emanuele Roscioli, Julie Welburn, Daniela Cimini, Matko Glunčić´, Nenad Pavin, Iva M Tolić
Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores.
Nat. Commun. 01/2016; 7:10298.
DOI:10.1038/ncomms10298
Link
Iva M. Tolić, Maja Novak, Nenad Pavin
Helical Twist and Rotational Forces in the Mitotic Spindle.
Biomolecules 04/2019; 9(4):132.
DOI:10.3390/biom90401
Link
P. Russotto, P.Z. Wu, M. Zoric, M. Chartier, Y. Leifels, R.C. Lemmon, Q. Li, J. Łukasik, A. Pagano, P. Pawłowski, W. Trautmann
Symmetry energy from elliptic flow in 197Au+197Au.
Phys. Lett. B 03/2011; 697(5-697):471-476.
DOI:10.1016/j.physletb.2011.02.033
Link
Anisur Rahaman, …, M. Zoric
Coulomb breakup of neutron-rich 29,30Na isotopes near the island of inversion.
J. Phys. G Nucl. Part. Phys. 02/2017; 44(4):045101.
DOI:10.1088/1361-6471/aa594d
Link
Ushasi Datta, ..., M. Zoric
Direct experimental evidence for a multiparticle-hole ground state configuration of deformed Mg 33.
Phys. Rev. C 09/2016; 94(3).
DOI:10.1103/PhysRevC.94.034304
Link
P. Russotto, ..., M. Zoric
Results of the ASY-EOS experiment at GSI: The symmetry energy at supra-saturation density.
Phys. Rev. C 09/2016; 94(3).
DOI:10.1103/PhysRevC.94.034608
Link
S.G. Altstadt, ..., M. Zoric, K. Zuber
B-13,B-14(n,gamma) via Coulomb Dissociation for Nucleosynthesis towards the r-Process.
Nucl. Data Sheets 07/2014; 120:197-200.
DOI:10.1016/j.nds.2014.07.045
Link
C. Caesar, ..., M. Zoric, K. Zuber
Beyond the neutron drip line: The unbound oxygen isotopes 25O and 26O.
Phys. Rev. C 09/2013; 88(034313):3.
DOI:10.1103/PhysRevC.88.034313
Link