Newest
Maja Novak: Hunting for vesicles and chromosomes under time constraints, Biophysical Journal, in press
The remarkable property of microtubules is a stochastic alternation between their growth and shrinkage, termed dynamic instability, which has been shown to be vital in their role in capturing and arranging cellular organelles in an orderly configuration, with the most striking examples being the reassembly of the Golgi complex after cell division, rapid aggregation of the pigment granules in fish melanophores, and congression of the chromosomes in the mitotic spindle. How this mechanism of search and capture, which was proposed 40 years ago, functions in various cellular contexts is an exciting area of research. Originally, the search-and-capture model described only microtubules as growing in a random direction, followed by their rapid shrinking and then re-growing in a different direction. This basic behavior was later augmented by a plethora of other mechanisms, such as microtubule branching, interactions with molecular motors, cross-linkers, and growth-modulating gradients, as well as microtubule pivoting, all of them aiding a more successful search.
All publications
Julian Rode, Maja Novak, Benjamin M. Friedrich
Information theory of chemotactic agents using both spatial and temporal gradient sensing.
PRX Life 07/2024; 2(2) 023012h
DOI: https://doi.org/10.1103/PRXLife.2.023012
Link
Andrea Auconi, Maja Novak, Benjamin M. Friedrich
Gradient sensing in Bayesian chemotaxis.
EPL 05/2022; 138 12001
DOI:10.1209/0295-5075/ac6620
Link
Maja Novak, Benjamin M. Friedrich
Bayesian gradient sensing in the presence of rotational diffusion.
New J. Phys. 04/2021; 23:043026.
DOI:10.1088/1367-2630/abdb70
Link
Maja Novak, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W. Thomae, Iva M. Tolić, Nenad Pavin
The mitotic spindle is chiral due to torques within microtubule bundles.
Nat. Commun. 12/2018; 9(1).
DOI:10.1038/s41467-018-06005-7
Link
Janko Kajtez, Anastasia Solomatina, Maja Novak, Bruno Polak, Kruno Vukušić, Jonas Rüdiger, Gheorghe Cojoc, Ana Milas, Ivana Š. Šestak, Patrik Risteski, Federica Tavano, Anna H Klemm, Emanuele Roscioli, Julie Welburn, Daniela Cimini, Matko Glunčić´, Nenad Pavin, Iva M Tolić
Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores.
Nat. Commun. 01/2016; 7:10298.
DOI:10.1038/ncomms10298
Link
Iva M. Tolić, Maja Novak, Nenad Pavin
Helical Twist and Rotational Forces in the Mitotic Spindle.
Biomolecules 04/2019; 9(4):132.
DOI:10.3390/biom90401
Link
P. Russotto, P.Z. Wu, M. Zoric, M. Chartier, Y. Leifels, R.C. Lemmon, Q. Li, J. Łukasik, A. Pagano, P. Pawłowski, W. Trautmann
Symmetry energy from elliptic flow in 197Au+197Au.
Phys. Lett. B 03/2011; 697(5-697):471-476.
DOI:10.1016/j.physletb.2011.02.033
Link
Anisur Rahaman, …, M. Zoric
Coulomb breakup of neutron-rich 29,30Na isotopes near the island of inversion.
J. Phys. G Nucl. Part. Phys. 02/2017; 44(4):045101.
DOI:10.1088/1361-6471/aa594d
Link
Ushasi Datta, ..., M. Zoric
Direct experimental evidence for a multiparticle-hole ground state configuration of deformed Mg 33.
Phys. Rev. C 09/2016; 94(3).
DOI:10.1103/PhysRevC.94.034304
Link
P. Russotto, ..., M. Zoric
Results of the ASY-EOS experiment at GSI: The symmetry energy at supra-saturation density.
Phys. Rev. C 09/2016; 94(3).
DOI:10.1103/PhysRevC.94.034608
Link
S.G. Altstadt, ..., M. Zoric, K. Zuber
B-13,B-14(n,gamma) via Coulomb Dissociation for Nucleosynthesis towards the r-Process.
Nucl. Data Sheets 07/2014; 120:197-200.
DOI:10.1016/j.nds.2014.07.045
Link
C. Caesar, ..., M. Zoric, K. Zuber
Beyond the neutron drip line: The unbound oxygen isotopes 25O and 26O.
Phys. Rev. C 09/2013; 88(034313):3.
DOI:10.1103/PhysRevC.88.034313
Link