[seminar] Seminar Auth, HFBD-IRB

[Hrvoje Buljan]

Pos(tovani, ljubazno sam zamoljen da oglasim seminar Thorstena Autha 
(iduci utorak):

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*ZAJEDNIC(KI SEMINAR*

*11. oz(ujak 2014. (utorak) **u 11:00 sati (toc(no)*

Institut za fiziku, Bijenic(ka cesta 46, Predavaonica III krilo

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*Thorsten Auth*

Forschungszentrum Jülich

Institute of Complex Systems (ICS)

Theorie der Weichen Materie und Biophysik

*Cellular uptake of nanoparticles by wrapping*

Nanoparticles have recently attracted increased interest due to a 
variety of potential applications. However, not much is known about 
their interaction with biological cells. Cellular uptake of particles, 
viruses, and parasites is a complex biological process: particles with 
sizes comparable to the thickness of the lipid bilayer enter by 
penetration, while particles with sizes of 20nm or larger get wrapped by 
the membrane. We calculate the energies for wrapping and characterize 
particle uptake analogously to thermodynamic phase transitions. We 
present wrapping phase diagrams for various curvature-elastic properties 
of the membrane, membrane-particle interaction strengths, and particle 
sizes and shapes. The transitions between unbound, partially-wrapped, 
and completely-wrapped states can be continuous or discontinuous and may 
involve reorientation of the particle. By systematic studies for the 
particle shape, we find that in particular elongated particles show 
reduced complete wrapping, but enhanced binding to the cell membrane.

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Thorsten Auth studied physics at Frankfurt University where he graduated 
in 2000. He moved to Forschungszentrum Jülich in 2001 and worked with 
Prof. Gerhard Gompper on simulations of polymer-membrane interactions, 
closely connected to experimental studies on oil-water microemulsions. 
Thorsten received his Ph.D. from University of Cologne in 2004. From 
2005 to 2007, he spent 2.5 years at the Weizmann Institute as a Minerva 
fellow, where worked with Prof. Nir Gov and Prof. Sam Safran on active 
fluctuations of red blood cells. After his return to Jülich, he works 
mainly on nanoparticle wrapping by lipid bilayer membranes and on 
collective behavior of self-propelled particles.

t.auth at fz-juelich.de <mailto:t.auth at fz-juelich.de>

www.fz-juelich.de/ics/ics-2/ <http://www.fz-juelich.de/ics/ics-2/>

http://www.fz-juelich.de/SharedDocs/Personen/ICS/ICS-2/EN/Auth_T.html?nn=539250

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