[Biofizika] Fwd: Biophysics post-doc in Paris

[Juraj Szavits Nossan]

-------- Forwarded Message --------
Subject: 	[info.statphys] Biophysics post-doc in Paris
Date: 	Tue, 29 May 2018 21:08:02 +0200
From: 	Claude Loverdo (claude.loverdo at gmail.com via info.statphys 
Mailing List) <info.statphys at listes.ens-lyon.fr>
Reply-To: 	Claude Loverdo <claude.loverdo at gmail.com>
To: 	info.statphys at listes.ens-lyon.fr



Post-doc: Modeling vaccination/niche competition in the gut for 
microbiota engineering

We are looking for a post doctoral researcher to model vaccination and 
niche competition effects in the gut for microbiota engineering. 
Antibiotic multi-resistant (AMR) bacteria that frequently inhabit the 
intestinal tract of humans and livestock are a serious threat. Our 
recent work demonstrates that intestinal antibodies, raised by 
inactivated oral vaccines, enforce the targeted strain to undergo 
"enchained growth", forming large clumps. During the project, a protocol 
combining vaccination with introduction of a niche competitor, for 
targeted drug-free removal of an individual bacterial strain from the 
microbiota of mice, will be developed, and extended to domestic pigs. 
Combining mathematical models and quantitative dynamic data will provide 
a solid framework for subsequent large-scale trials and extension to 
more diverse bacterial species and hosts.

The postdoc will analyze experimental data to extract information about 
the bacterial populations dynamics. He/she will develop biophysical 
models of the microbiota dynamics in the gut, integrating immune 
dynamics and competition, and animal size and physiology. Beyond the 
direct applications to the experiments of the project, the goal is to 
gain a better understanding on how the physical conditions in the gut 
interplay with the microbiota dynamics.

The postdoc will be based in Sorbonne Université, Paris, under the 
supervision of Claude Loverdo, and the work will be in close 
collaboration with Emma Slack, ETH Zürich. The postdoc will be 
integrated to the theory team of the Laboratoire Jean Perrin, a young 
and dynamic biophysical lab, in the center of Paris. The postdoc 
duration is 12+ months, start date negotiable from September 2018, with 
salary according to experience.

The candidate should have a PhD (or have it completed before the start 
of the position), in physics or a related field, and a strong experience 
in modeling. Moreover he/she should have a deep interest and possibly a 
previous experience in biology.

If you are interested please send us a CV and a short email motivating 
your interest in the position.
Claude Loverdo claude.loverdo at upmc.fr <mailto:claude.loverdo at upmc.fr>
Emma Slack emma.slack at micro.biol.ethz.ch 
<mailto:emma.slack at micro.biol.ethz.ch>

Most relevant publications:
- K.Moor, M.Diard, M.E.Sellin, B.Felmy, S.Y.Wotzka, A.Toska, E.Bakkaren, 
M.Arnoldini, F.Bansept, A.Dal Co, T.Voller, A.Minola, 
B.Fernandez-Rodriguez, G.Agatic, S.Barbieri, L.Piccoli, C.Casiraghi, 
D.Corti, A.Lanzavecchia, R.R.Regoes, C.Loverdo, R.Stocker, D.R.Brumley, 
W-D.Hardt, E.Slack. High-avidity IgA protects the intestine by 
enchaining growing bacteria. Nature 544:498--502 (2017)
- M.Diard, E.Bakkaren, J.K.Cornuault, A.Hausmann, K.Moor, M.E.Sellin, 
C.Loverdo, A.Aertsen, M.Ackermann, M.De Paepe, E.Slack, W-D.Hardt. 
Inflammation boosts bacteriophage transfer between Salmonella spp. 
Science 355:1211--1215 (2017)
- F.Bansept, K.Schumann-Moor, M.Diard, W-D.Hardt, E.Slack, C.Loverdo,  
Enchained growth and cluster dislocation : a possible mechanism for 
microbiota homeostasis, bioRxiv:298059
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