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<td>[info.statphys] Biophysics post-doc in Paris</td>
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<td>Tue, 29 May 2018 21:08:02 +0200</td>
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<th valign="BASELINE" align="RIGHT" nowrap="nowrap">From: </th>
<td>Claude Loverdo (<a class="moz-txt-link-abbreviated" href="mailto:claude.loverdo@gmail.com">claude.loverdo@gmail.com</a> via
info.statphys Mailing List)
<a class="moz-txt-link-rfc2396E" href="mailto:info.statphys@listes.ens-lyon.fr"><info.statphys@listes.ens-lyon.fr></a></td>
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<th valign="BASELINE" align="RIGHT" nowrap="nowrap">Reply-To:
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<td>Claude Loverdo <a class="moz-txt-link-rfc2396E" href="mailto:claude.loverdo@gmail.com"><claude.loverdo@gmail.com></a></td>
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<th valign="BASELINE" align="RIGHT" nowrap="nowrap">To: </th>
<td><a class="moz-txt-link-abbreviated" href="mailto:info.statphys@listes.ens-lyon.fr">info.statphys@listes.ens-lyon.fr</a></td>
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<br>
<div dir="ltr">Post-doc: Modeling vaccination/niche competition in
the gut for microbiota engineering<br>
<br>
We are looking for a post doctoral researcher to model
vaccination and niche competition effects in the gut for
microbiota engineering. Antibiotic multi-resistant (AMR)
bacteria that frequently inhabit the intestinal tract of humans
and livestock are a serious threat. Our recent work demonstrates
that intestinal antibodies, raised by inactivated oral vaccines,
enforce the targeted strain to undergo "enchained growth",
forming large clumps. During the project, a protocol combining
vaccination with introduction of a niche competitor, for
targeted drug-free removal of an individual bacterial strain
from the microbiota of mice, will be developed, and extended to
domestic pigs. Combining mathematical models and quantitative
dynamic data will provide a solid framework for subsequent
large-scale trials and extension to more diverse bacterial
species and hosts.<br>
<br>
The <span
class="gmail-m_-2133579034334562330m_-5501323535424736752gmail-il">postdoc</span>
will analyze experimental data to extract information about the
bacterial populations dynamics. He/she will develop biophysical
models of the microbiota dynamics in the gut, integrating immune
dynamics and competition, and animal size and physiology. Beyond
the direct applications to the experiments of the project, the
goal is to gain a better understanding on how the physical
conditions in the gut interplay with the microbiota dynamics. <br>
<br>
The <span
class="gmail-m_-2133579034334562330m_-5501323535424736752gmail-il">postdoc</span>
will be based in Sorbonne Université, Paris, under the
supervision of Claude Loverdo, and the work will be in close
collaboration with Emma Slack, ETH Zürich. The <span
class="gmail-m_-2133579034334562330m_-5501323535424736752gmail-il">postdoc</span>
will be integrated to the theory team of the Laboratoire Jean
Perrin, a young and dynamic biophysical lab, in the center of
Paris. The <span
class="gmail-m_-2133579034334562330m_-5501323535424736752gmail-il">postdoc</span>
duration is 12+ months, start date negotiable from September
2018, with salary according to experience. <br>
<br>
The candidate should have a PhD (or have it completed before the
start of the position), in physics or a related field, and a
strong experience in modeling. Moreover he/she should have a
deep interest and possibly a previous experience in biology.<br>
<br>
If you are interested please send us a CV and a short email
motivating your interest in the position.<br>
Claude Loverdo <a href="mailto:claude.loverdo@upmc.fr"
target="_blank" moz-do-not-send="true">claude.loverdo@upmc.fr</a>
<br>
Emma Slack <a href="mailto:emma.slack@micro.biol.ethz.ch"
target="_blank" moz-do-not-send="true">emma.slack@micro.biol.ethz.ch</a>
<br>
<br>
Most relevant publications: <br>
- K.Moor, M.Diard, M.E.Sellin, B.Felmy, S.Y.Wotzka, A.Toska,
E.Bakkaren, M.Arnoldini, F.Bansept, A.Dal Co, T.Voller,
A.Minola, B.Fernandez-Rodriguez, G.Agatic, S.Barbieri,
L.Piccoli, C.Casiraghi, D.Corti, A.Lanzavecchia, R.R.Regoes,
C.Loverdo, R.Stocker, D.R.Brumley, W-D.Hardt, E.Slack.
High-avidity IgA protects the intestine by enchaining growing
bacteria. Nature 544:498--502 (2017)<br>
- M.Diard, E.Bakkaren, J.K.Cornuault, A.Hausmann, K.Moor,
M.E.Sellin, C.Loverdo, A.Aertsen, M.Ackermann, M.De Paepe,
E.Slack, W-D.Hardt. Inflammation boosts bacteriophage transfer
between Salmonella spp. Science 355:1211--1215 (2017)<br>
- F.Bansept, K.Schumann-Moor, M.Diard, W-D.Hardt, E.Slack,
C.Loverdo, Enchained growth and cluster dislocation : a
possible mechanism for microbiota homeostasis, bioRxiv:298059<br>
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