[Biofizika] [Ebsa] ERC funded postdoc position in chromatin dynamics

[Beat Fierz]

News associated with biophysics - supported by the European Biophysical Societies' Association (EBSA) - www.ebsa.org/

-----

Our laboratory of Biophysical Chemistry of Macromolecules (LCBM) at the 
EPFL in Lausanne, Switzerland offers two fully funded position on the 
postdoctoral level in the field of in Biophysical Chemistry of Chromatin 
for the ERC funded project “Chromo-SUMMIT: Decoding dynamic chromatin 
signaling by single-molecule multiplex detection”

Transient multivalent interactions are critical for biological processes 
such as signaling pathways controlling chromatin function. Chromatin, 
the nucleoprotein complex organizing the genome, is dynamically 
regulated by post-translational modifications (PTMs) of the chromatin 
fiber. Protein effectors interact with combinations of these PTMs 
through multivalent interactions, deposit novel PTMs, thereby propagate 
signaling cascades and remodel chromatin structure.

To reveal the underlying molecular mechanisms, methods outside classical 
biochemistry are required, in particular due to the combinatorial 
complexity of chromatin PTMs and the transient supramolecular 
interactions crucial for their recognition.

The aim of this project is thus to develop a novel approach, combining 
designer chromatin synthesis and dynamic multiplex single-molecule 
imaging, to dissect multivalent signaling processes in chromatin - with 
a focus on the DNA damage response.

Qualifications
The ideal candidates for this position have a PhD in biochemistry, 
biophysics or a related field and have a strong interest in elucidating 
molecular mechanisms in chromatin regulation. We are particular looking 
for candidates with a strong background in:
- single-molecule methods in biological systems
- protein purification handling and characterization
- protein and peptide chemistry
- quantitative / systems biology and modeling.

The position will start in Mai 2017.

To apply for the position, please send a letter of motivation, a CV and 
the contact information of two referees to: Prof. Beat Fierz - 
beat.fierz at epfl.ch

With best regards,
Beat Fierz, PhD

École Polytechnique Fédérale de Lausanne
SB  ISIC  LCBM CH B3 485
Station 6
CH-1015 Lausanne
Switzerland
tél: +41 21 69 37153
http://lcbm.epfl.ch/
-----
Should you like to unsubscribe from this list, get a password reminder, or change your subscription options, please go to https://listmail.tut.fi/mailman/listinfo/ebsa.