<html><body><div style="font-family: arial,helvetica,sans-serif; font-size: 12pt; color: #000000"><div><br></div><div style="color:#000;font-weight:normal;font-style:normal;text-decoration:none;font-family:Helvetica,Arial,sans-serif;font-size:12pt;" data-mce-style="color: #000; font-weight: normal; font-style: normal; text-decoration: none; font-family: Helvetica,Arial,sans-serif; font-size: 12pt;"><div style="font-family: arial,helvetica,sans-serif; font-size: 12pt; color: #000000" data-mce-style="font-family: arial,helvetica,sans-serif; font-size: 12pt; color: #000000;"><p style="margin: 0px;" data-mce-style="margin: 0px;"><b><span lang="HR"> Poštovani,</span></b></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><b><span lang="HR"><br>podsjećamo Vas na <span style="color: rgb(255, 0, 0);">današnji</span> seminar na Institutu za fiziku u <span style="color: rgb(255, 0, 0);">11:00</span> sati:<br><br></span></b></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><br></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span lang="HR"> </span></p><p style="margin: 0px; text-align: center;" data-mce-style="margin: 0px; text-align: center;"><span lang="HR"><img src="cid:96a0879478ab2486466011d744bd9b41f3b5c969@zimbra" data-mce-src="cid:96a0879478ab2486466011d744bd9b41f3b5c969@zimbra" width="200"> <img src="cid:de0aa620b23ece4e88c650568cdd28db12d5950b@zimbra" data-mce-src="cid:de0aa620b23ece4e88c650568cdd28db12d5950b@zimbra" width="180"></span></p><p style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span lang="HR"> </span></p><p style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span lang="HR"> </span></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><b><span style="font-size: 16.0pt;" data-mce-style="font-size: 16.0pt;" lang="HR"> </span></b></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><b><span style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" lang="HR"> </span></b></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><b><span style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" lang="HR">ZAJEDNIČKI SEMINAR </span></b></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><b><span style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" lang="HR">Hrvatskog biofizičkog društva i Instituta za fiziku</span></b></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><b><span style="font-family: 'Calibri','sans-serif';" data-mce-style="font-family: 'Calibri','sans-serif';" lang="HR">11. ožujka 2014. (utorak) </span></b><b><span style="font-family: 'Calibri','sans-serif';" data-mce-style="font-family: 'Calibri','sans-serif';" lang="HR">u 11:00 sati (točno)</span></b></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span style="font-family: 'Calibri','sans-serif';" data-mce-style="font-family: 'Calibri','sans-serif';" lang="HR">Institut za fiziku, Bijenička cesta 46, predavaonica u III krilu</span></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span style="font-family: 'Calibri','sans-serif';" data-mce-style="font-family: 'Calibri','sans-serif';" lang="HR"> </span></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><b><span style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" lang="HR"> </span></b></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><b><span style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" lang="HR"> </span></b></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><b><span style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" lang="HR">Thorsten Auth</span></b></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span style="font-family: 'Calibri','sans-serif';" data-mce-style="font-family: 'Calibri','sans-serif';" lang="HR">Forschungszentrum Jülich</span></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span style="font-family: 'Calibri','sans-serif';" data-mce-style="font-family: 'Calibri','sans-serif';" lang="HR">Institute of Complex Systems (ICS)</span></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span style="font-family: 'Calibri','sans-serif';" data-mce-style="font-family: 'Calibri','sans-serif';" lang="HR">Theorie der Weichen Materie und Biophysik</span></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span style="font-size: 11.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 11.0pt; font-family: 'Calibri','sans-serif';" lang="HR"> </span></p><p class="Default" style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><span style="font-size: 11.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 11.0pt; font-family: 'Calibri','sans-serif';" lang="HR"> </span></p><p style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><strong><span style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';">Cellular uptake of nanoparticles by wrapping</span></strong></p><p style="text-align: center; margin: 0px;" data-mce-style="text-align: center; margin: 0px;" align="center"><strong><span style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';" data-mce-style="font-size: 16.0pt; font-family: 'Calibri','sans-serif';"><br></span></strong></p><p style="text-align: justify; margin: 0px;" data-mce-style="text-align: justify; margin: 0px;"><span style="font-family: 'Calibri','sans-serif';" data-mce-style="font-family: 'Calibri','sans-serif';">Nanoparticles have recently attracted increased interest due to a variety of potential applications. However, not much is known about their interaction with biological cells. Cellular uptake of particles, viruses, and parasites is a complex biological process: particles with sizes comparable to the thickness of the lipid bilayer enter by penetration, while particles with sizes of 20nm or larger get wrapped by the membrane. We calculate the energies for wrapping and characterize particle uptake analogously to thermodynamic phase transitions. We present wrapping phase diagrams for various curvature-elastic properties of the membrane, membrane-particle interaction strengths, and particle sizes and shapes. The transitions between unbound, partially-wrapped, and completely-wrapped states can be continuous or discontinuous and may involve reorientation of the particle. By systematic studies for the particle shape, we find that in particular elongated particles show reduced complete wrapping, but enhanced binding to the cell membrane. </span><span></span></p><div><br style="font-size: 11.0pt; font-family: 'Calibri','sans-serif'; color: black;" data-mce-style="font-size: 11.0pt; font-family: 'Calibri','sans-serif'; color: black;"></div><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-size: 11.0pt; font-family: 'Calibri','sans-serif'; color: black;" data-mce-style="font-size: 11.0pt; font-family: 'Calibri','sans-serif'; color: black;"><a href="mailto:t.auth@fz-juelich.de" target="_blank" data-mce-href="mailto:t.auth@fz-juelich.de">t.auth@fz-juelich.de</a></span><br></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span style="font-size: 11.0pt; font-family: 'Calibri','sans-serif'; color: black;" data-mce-style="font-size: 11.0pt; font-family: 'Calibri','sans-serif'; color: black;"><a href="http://www.fz-juelich.de/ics/ics-2/" target="_blank" data-mce-href="http://www.fz-juelich.de/ics/ics-2/">www.fz-juelich.de/ics/ics-2/</a></span><br></p><p style="margin: 0px;" data-mce-style="margin: 0px;"><span data-mce-style="font-size: 11.0pt; font-family: 'Calibri','sans-serif'; color: black;"><a href="http://www.fz-juelich.de/SharedDocs/Personen/ICS/ICS-2/EN/Auth_T.html?nn=539250" target="_blank" data-mce-href="http://www.fz-juelich.de/SharedDocs/Personen/ICS/ICS-2/EN/Auth_T.html?nn=539250">http://www.fz-juelich.de/SharedDocs/Personen/ICS/ICS-2/EN/Auth_T.html?nn=539250</a></span><br data-mce-bogus="1"></p></div></div></div></body></html>