[seminar] Seminar na IF-u, 11. ožujka 2014. (utorak) u 11:00h

[Osor Barisic]

ZAJEDNIČKI SEMINAR 

Hrvatskog biofizičkog društva i Instituta za fiziku 

11. ožujka 2014. (utorak) u 11:00 sati (točno) 

Institut za fiziku, Bijenička cesta 46, predavaonica u III krilu 







Thorsten Auth 

Forschungszentrum Jülich 

Institute of Complex Systems (ICS) 

Theorie der Weichen Materie und Biophysik 





Cellular uptake of nanoparticles by wrapping 




Nanoparticles have recently attracted increased interest due to a variety of potential applications. However, not much is known about their interaction with biological cells. Cellular uptake of particles, viruses, and parasites is a complex biological process: particles with sizes comparable to the thickness of the lipid bilayer enter by penetration, while particles with sizes of 20nm or larger get wrapped by the membrane. We calculate the energies for wrapping and characterize particle uptake analogously to thermodynamic phase transitions. We present wrapping phase diagrams for various curvature-elastic properties of the membrane, membrane-particle interaction strengths, and particle sizes and shapes. The transitions between unbound, partially-wrapped, and completely-wrapped states can be continuous or discontinuous and may involve reorientation of the particle. By systematic studies for the particle shape, we find that in particular elongated particles show reduced complete wrapping, but enhanced binding to the cell membrane. 



t.auth at fz-juelich.de 


www.fz-juelich.de/ics/ics-2/ 


http://www.fz-juelich.de/SharedDocs/Personen/ICS/ICS-2/EN/Auth_T.html?nn=539250 







-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://www.phy.pmf.unizg.hr/pipermail/seminar/attachments/20140305/4b699101/attachment-0001.html>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image003.jpg
Type: image/jpeg
Size: 93084 bytes
Desc: not available
URL: <http://www.phy.pmf.unizg.hr/pipermail/seminar/attachments/20140305/4b699101/attachment-0001.jpg>
-------------- next part --------------
A non-text attachment was scrubbed...
Name: image001.png
Type: image/png
Size: 20913 bytes
Desc: not available
URL: <http://www.phy.pmf.unizg.hr/pipermail/seminar/attachments/20140305/4b699101/attachment-0001.png>