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<span lang="EN-GB">A post-doc position founded by Pfizer through a Global Medical Grant is available at the University of Udine (Italy) in the Biophysics lab of Prof. Alessandra Corazza.<o:p> </o:p></span></p>
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<span lang="EN-GB">The successful candidate will study the effect of shear forces on the amyloidogenic protein transthyretin (TTR) by NMR. The project
</span><span style="mso-ansi-language:EN-US" lang="EN-US">arises in the framework of the mechano-enzymatic amyloidogenesis model proposed for TTR amyloidosis (ATTR) and aims to elucidate the role of mechanical forces in the proteolytic event leading to protein
aggregation at the molecular level. </span><span lang="EN-GB">Rheo-NMR will be used to investigate these processes at atomic resolution. In addition, interaction with mono- and bi-valent TTR stabilizers will be elucidated.</span><span style="font-family:"Times New Roman",serif;mso-ascii-font-family:Calibri;mso-ascii-theme-font:minor-latin" lang="EN-GB"> </span><span style="mso-ansi-language:EN-US" lang="EN-US">The
post-doc is expected to carry out solution state NMR experiments with a focus on protein structure and dynamics.
</span><span lang="EN-GB"><o:p> </o:p></span></p>
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<span style="mso-ansi-language:EN-US" lang="EN-US">The work will be carried out in collaboration with the Amyloid Unit Research at the University of Pavia and the
</span><span lang="EN-GB">Centre for Amyloidosis and Acute Phase Proteins at University College London.<o:p> </o:p></span></p>
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<span lang="EN-GB">The initial appointment is for one year starting from 1 December 2022, with the possibility of renewal.<o:p> </o:p></span></p>
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<span lang="EN-GB">The applicant should be highly motivated and have a background in NMR spectroscopy.<o:p> </o:p></span></p>
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<span lang="EN-GB">Applicants must submit before 30 September a cover letter summarizing research experience, a CV (including a publication list) and two reference contacts to
<a href="mailto:alessandra.corazza@uniud.it">alessandra.corazza@uniud.it</a><span class="MsoHyperlink" style="color:rgb(5, 99, 193);text-decoration:underline"><span style="color:black;mso-themecolor:text1;text-underline:none"> and
</span></span><a href="mailto:cristina.cantarutti@uniud.it">cristina.cantarutti@uniud.it</a><span class="MsoHyperlink" style="color:rgb(5, 99, 193);text-decoration:underline"><span style="color:black;mso-themecolor:text1;text-underline:none">.<o:p> </o:p></span></span></span></p>
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