<html><head><meta http-equiv="Content-Type" content="text/html charset=windows-1252"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;">Post-doc Researcher in the Group of Computational Biophysics<br><br>The Group of Computational Biophysics at the Physics Department of the University of Cagliari is opening a two-years Post-doc position on timely problems related to multidrug bacterial resistance mediated by efflux systems (more info at <a href="http://www.dsf.unica.it/~paolo/">www.dsf.unica.it/~paolo/</a>). The position is within the framework of the IMI - ND4BB action (Innovative Medicine Initiative -New Drugs for Bad Bugs, see <a href="http://www.imi.europa.eu/content/translocation">http://www.imi.europa.eu/content/translocation</a>). The Group is also involved in a second project under the ITN-Marie Curie action (<a href="http://cordis.europa.eu/project/rcn/109792_it.html">http://cordis.europa.eu/project/rcn/109792_it.html</a>).<br><br>Tasks<br> MD simulations with standard and biased techniques to study the interaction of specific compounds with bacterial efflux pumps.<br> Evaluation of thermodynamics and kinetics parameters associated with the compound-efflux pump interactions.<br> Molecular modelling of efflux pumps in their apo form and in complex with compounds.<br> Interactions with all research partners of the multidisciplinary project.<span class="Apple-tab-span" style="white-space: pre;"> </span><br><br>Requirements<br> PhD in Physics, Chemistry, Bioinformatics, Computational biology, Pharmaceutical Chemistry, Biotechnology.<br> Strong publication record in the field of molecular simulation/ molecular modelling.<br> Experience in the use of most common molecular modelling/simulation packages (gromacs, amber, namd, modeller,..) and of methods to evaluate free energies.<br> Desiderable experience in quantum chemistry methods and hybrid QM/MM codes.<br> Fluent written and spoken English.<span class="Apple-tab-span" style="white-space: pre;"> </span><br><br>We offer<br> Fixed-term position (2 years).<br> Dynamic and productive working environment.<br> Interdisciplinary collaboration with world-leading international research groups including scientists of GlaxoSmithKlein, Sanofi-Aventis, Basilea Pharmaceutica Ltd.<br> Travel support to participate to international conferences and workshops.<span class="Apple-tab-span" style="white-space: pre;"> </span><br><br><br>Information on the position including a template of the application form will be available at the following link<br><a href="http://dirpersonale.unica.it/concorsi/index.php?page=assegni&bando=599">http://dirpersonale.unica.it/concorsi/index.php?page=assegni&bando=599</a><br>The candidate should provide at least two reference letters.<br><br>For further information, please contact<br>Paolo Ruggerone<br>T: +390706754922<br><a href="mailto:paolo.ruggerone@dsf.unica.it">paolo.ruggerone@dsf.unica.it</a><br><div apple-content-edited="true">
<div style="color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div style="color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div style="color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div style="color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;"><div style="color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px;"><div><br class="Apple-interchange-newline"> <a href="smb://|/">\\|/</a>/</div><div> (^ ^)</div><div>/------------------ooO-(_)-Ooo-----------------\</div><div>| Paolo Ruggerone | </div><div>| Dipartimento di Fisica | </div><div>| Universitΰ di Cagliari |</div><div>| Cittadella Universitaria |</div><div>| S.P. Monserrato-Sestu Km 0.700 |<span class="Apple-converted-space"> </span><span class="Apple-converted-space"></span><span class="Apple-converted-space"></span></div><div>| I-09042 MONSERRATO (CA), Italy |</div><div>| tel +39 070 6754922 |</div><div>| fax +39 070 6753191 |</div><div>| <a href="mailto:paolo.ruggerone@dsf.unica.it">paolo.ruggerone@dsf.unica.it</a> |</div><div>| skype: paolorug |</div><div>\----------------------------------------------------/</div><div> || ||</div><div> (_) (_)</div></div></div></div></div></div>
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